Laboratory of Applied Statistics and BioMedical Computing - Collaborations, activities of the laboratory

The laboratory of Applied Statistics and BioMedical Computing develops methods of data analysis, mathematical tools and data processing and takes part in research projects. It is associated with the research pole of the University of Caen and more particularly with the Research Laboratory in Physical and Sporting Activities (CRAPS STAPS of University of Caen) and the Regional Institute of Sport Medicine (IRMS CHU of Caen). The laboratory has promptly collaborated with a laboratory of the INSERM of the Kremlin Bicètre Hospital and with a laboratory of Radio-analysis in Lyon Hospices Civils in the application field of innovative biostatistical methods applied to Molecular Biology (Telomeres structure), Cellular Biology (Hepatocytes) and Human Biochemistry (metabolism of Melatonin)

The scientific publications made it possible to refine and to make public the work on the Chronobiometry field. In particular, the remarkable studies that resulted from the work of Jean de Prins, Pietro Cugini, Walter Nelson, Germaine Cornélissen, Christopher Bingham and their scientific collaborators are noteworthy here.

In this context, Laurent Gouthière is a methodologist and worked on the research field of modelling expert systems :

Gaudeau C., Gouthiere L., Le Toullec C., Lawton E. and Chauvet G. (1990). Simulation Expert System for Physiological Mechanisms of the Space Motion Sickness. Life Sciences Research in Space, Trieste Italy, European Space Agency, ESA SP-307, 111-116.

(1, 2, 3, 4) BioComputing laboratory, BioComputing and BioTechnology society, Tours, France, (1, 2) Conservatoire National des Arts et Métiers, Tours, France, (5) Laboratory of Theoretical Biology, University of Angers, France.

Gaudeau C., Gouthiere L. (1992). Méthodologie d'analyse des rythmes dans les systèmes non linéaires. Les rythmes, lectures et théories. Converscienses, L'Harmattan. 31-56.

In the field of time series analysis, among new methods of detection of rhythms or more generally, of periodic phenomena (spectral analysis), one can cite: the "Reverse Elliptic Spectrum" and the "Percent Rhythm Spectrum". Laurent Gouthière (Associated researcher of the CRAPS STAPS University of Caen) is a member of the French Society of Chronobiology (SFC) and the French Society of Statistics (SFdS)

Gouthière L. (2003). Séminaire de recherche sur les approches pluridisciplinaires du mouvement humain et de la pratique sportive à l'UFR STAPS de Caen, (Statistical study of the analysis of a bioperiodic phenomenon). Chronobiométrie et méthodologie d'analyses des rythmes biologiques. UFR STAPS, March 27th 2003.

(flash slides),

Mauvieux B., Gouthière L., Sesboüe B. et Davenne D. (2003). (Compared studies of the the circadian rhythms and the sleep actimetric reflect of sportive subjects and sedentariness subjects engaged in night-shift work). Etudes comparées des rythmes circadiens de la température et reflet actimétrique du sommeil de sportifs et sédentaires en poste régulier de nuit. (Full text ) Can J Appl Physiol. 2003 Dec;28(6):831-87. French. (PMID: 14992125)

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France (2) Laboratory of applied Statistics and biomedical computing (Expert Soft Tech.) Esvres, France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France.

Deschatrette J., Ng KH, Gouthière L., Maigné J., Gerroui S. and Wolfrom C. (2004). Telomere dynamics determine episodes of anticancer drug resistance in rat hepatoma cells. Anticancer Drugs. 2004 Aug;15(7):671-8. (PMID: 15269598)

(1, 2, 4, 5, 6) INSERM U347, the Kremlin-Bicétre Hospital, le Kremlin Bicétre, France, (3) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres France.

Gouthière L., Claustrat B., Brun J. et Mauvieux B. (2005). (Complementary methodological steps in the analysis of rhythms: search of periods, modelling. Examples of plasma melatonin and temperature curves). Eléments méthodologiques complémentaires dans l'analyse des rythmes: recherche de périodes, modélisation. Exemples de la Mélatonine plasmatique et de courbes de températures. (Full text ) Pathol Biol (Paris). 2005 Jun;53(5):285-9. Epub 2005 Jan 28. French. (PMID: 15939140)

(1) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres, France, (2, 3) Radiopharmacy and radioanalysis, Nuclear medicine center, Neurocardiologic Hospital, Lyon, France, (4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France.

(1) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres, France, (2, 3) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (4) Research institute for sport and exercise sciences, John Moores University, Liverpool, UK.

Gouthière L., Mauvieux B. (2005). (Chronobiological Time Series, data quality and modelisation). Séries temporelles chronobiologiques : qualité des données, modélisation. Rythmes 2005 Dec;36(4):99-106.

(Full text )

(1) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres France, (2) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France.

Mauvieux B., Gouthière L., Sesboue B., Denise P., Davenne D. (2007). (Effects of the sportive and physical training on the temperature and night and day rhythm on the ederly. Example of retired people and night work workers). Effets de l'entraînement physique et sportif sur le rythme circadien de la température et le rythme veille–sommeil chez la personne vieillissante. Exemples chez des retraités et des travailleurs de nuit. Pathol Biol (Paris). 2007 Mar 26; French. (PMID: 17391866)

(1, 2, 5) Laboratory of the research center in physical and sportive activity (CRAPS–UPRES EA2131) university of Caen Basse-Normandie, UFR STAPS of Caen, 2, boulevard Maréchal-Juin, F-14032 Caen cedex, France. (2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), 7, chemin de la Birotte, F-37320 Esvres France. (3) Regional Institute of sport medicine (IRMS), CHU of Caen, F-14033 Caen cedex, France. (4) Laboratory of Physiology, CHU of Caen, F-14033 Caen cedex, France.

Gouthière L., Mauvieux B. (2004). (Essential steps in the analysis of the rhythms: Quality of the experimental data, search for periods by spectral analysis of various principles, modelling). Etapes essentielles dans l'analyse des rythmes : Qualité des données expérimentales, Recherche de périodes par analyses spectrales de principes divers, Modélisation. XXXVème Congrès de la Société Francophone de Chronobiologie, Sur quelques aspects de la Chronobiologie. Publications de l'Université de Saint-Etienne (Jean Monnet), ISBN: 2-86272-342-8, July 2004.

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(1) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.) Esvres, France, (2) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France.

Mauvieux B., Gouthière L., Sesboüe B. et Davenne D. (2004). (Comparative studies of the circadian rhythms and actimetric reflect of the sleep quality of sportive and sedentariness workers in night-shift work). Comparaisons des rythmes circadiens de la température et reflet actimétrique du sommeil de sportifs et de sédentaires en poste régulier de nuit. XXXVème Congrès de la Société Francophone de Chronobiologie, Sur quelques aspects de la Chronobiologie. Publications de l'Université de Saint-Etienne (Jean Monnet), July 2004. (Full text )

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (2) Laboratory of applied statistics and biomedical computing, (Expert Soft Tech.) Esvres, France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France.

Larousserie D., Mauvieux B. (2005). Physiologie : Sport et travail de nuit (Physiology: Sport and night shift work). Sciences et Avenir. 2005 Dec;706:35.

(1) Sciences et Avenir magazine, France, (2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.) Esvres, France and laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France.

Gouthière L., Mauvieux B. (2003). (Essential steps in the analysis of the rhythms: Quality of the experimental data, search for periods by spectral analysis of various principles, modelling). Etapes essentielles dans l'analyse des rythmes : Qualité des données expérimentales, Recherche de périodes par analyses spectrales de principes divers, Modélisation. XXXVth Congress of the French Society of Chronobiology, Faculté des Sciences et Techniques, University of Saint-Etienne, France, June 10-12 2003. (Abstract )

Mauvieux B., Gouthière L., Sesboüe B., Davenne D. (2003). (Comparative studies of the circadian rhythms and actimetric reflect of the sleep quality of sportive and sedentariness workers in night-shift work). Etudes comparées du rythme circadien de la température et reflet actimétrique de la qualité du sommeil de sportifs et de sédentaires en poste de nuit. XXXVth Congress of the French Society of Chronobiology, University of Saint-Etienne, France, June 10-12 2003. (Abstract )

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (2) Laboratory of applied statistics (Expert Soft Tech.) Esvres, France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France.

Gouthière L. (2003). Complementary methodological approach in the rhythms analysis : Quality, period, modelling (Approche méthodologique complémentaire dans l'analyse des rythmes : Qualité, période, modélisation). XIIIth Congress of the French Medical Association of Chronobiology, VTF Saint Sauves, La Bourboule, France, September 25-28 2003. (Abstract )

Mauvieux B., Gouthière L., Sesboüe B., Davenne D. (2004). (Effects of physical and sportive training on the circadian rhythms of the night-shift workers). Effets de l’entrainement physique et sportif sur les rythmes circadiens du travailleur en poste regulier de nuit. XXXVIth Congress of the French Society of Chronobiology, University of Rennes, France. (Abstract ), (White paper )

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France (2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.) Esvres, France, (3) Regional Institute of Sport Medicine (IRMS), CHU of Caen, France.

Gouthière L., Wolfrom C. et Deschatrette J. (2004). (Reverse Elliptic Periodogram (REP): principle, interest, example of the periods of the cells proliferation rate of transformed human fibroblasts, HGK1 cells). Spectre Elliptique Inverse, principe, intérêt, exemple des périodicités de la vitesse de prolifération de fibroblastes humains transformés (cellules HGK1). XXXVIth Congress of the French Society of Chronobiology, University of Rennes, France, May 17-19 2004. (Abstract ), (Flash slides), (White paper )

(1) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres France, (2, 3) INSERM U347, the Kremlin-Bicétre Hospital, le Kremlin Bicétre, France.

Mauvieux B., Gouthière L., Sesboué B., Denise P. et Davenne D. (2005). (Effects of the physical training and the sportive activity on the circadian rhythm of the temperature and the night and day rhythm for aging people. Example for retired and night workers). Effets de l'entrainement physique et sportif sur le rythme circadien de la température et le rythme veille-sommeil chez la personne vieillissante. Exemple chez des retraités et des travailleurs de nuit. XIVth Congress of the French Medical Association of Chronobiology, Centre Paul Langevin, Aussois, France, March 10-13 2005. (Abstract )

(1, 5) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France, (4) Laboratory of Physiology, CHU of Caen, France.

Mauvieux B., Gouthière L., Sesboué B. et Davenne D. (2005). (Effects of a regular sportive programme of training on the biological rhythms of the night workers). Effets de l'entraînement physique et sportif régulier sur les rythmes biologiques du travailleur de nuit. XXXVIIth Congress of the French Society of Chronobiology, University of Strasbourg, France, April 18-20 2005. (Abstract )

(1, 5) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (1, 2) Laboratory of applied statistics and biomedical Computing (Expert Soft Tech.), Esvres France, (3) Regional Institute of Sport Medicine (IRMS), CHU of Caen, France,

Claustrat B., Frezet S., Gouthière L., Malan A., Brun J. and Claustrat F. (2005). Alteration of daily urine 6-sulfatoxymelatonin, plasma corticosterone and hepatic clock gene expression in the folate deficient CBA mouse. Xth Congress of the European Pineal and Biological Rhythms Society, September 1st-5th, 2005 - Frankfurt / Main, Germany. (Abstract )

(1, 2, 5, 6) Radiopharmacy and radioanalysis, Nuclear Medicine Center, Neurocardiologic Hospital, Lyon, France, (3) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres, France, (4) Neurobiology of the Rhythms, CNRS and Louis Pasteur University, Strasbourg, France.

Mauvieux B., Gouthière L., Sesboüe B. and Davenne D. (2006). (Chronobiology and health of night workers : How physical and sportive training can slow down the phenomenon of desynchronization of the biological rhythms ?). Chronobiologie et santé des travailleurs de nuit : Comment l’entraînement physique et sportif peut ralentir le phénomène de désynchronisation des rythmes biologiques ? XXXXIth Congress of the French Language Society of Ergonomics (SELF) , September 11-13, 2006, Caen, France.

(1, 2, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (1, 2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres, France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France.

Mauvieux B., Gouthière L., Sesboüe B. et Davenne D. (2003). (Effects of a sportive programme of training on the biological rhythms and on the sleep quality in an extreme situation: Example of the regular night work). Les effets d'un programme d'entraînement sportif sur les rythmes biologiques et sur la qualité du sommeil en situation extrême : Exemple du travail régulier de nuit. Xème Congrès International des Chercheurs en Activités Physiques et Sportives, Paul Sabatier University of Toulouse, France, October 30-31, November 1st 2003. (Abstract ), (Poster )

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France (2) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres France, (3) Regional institute of sport medicine (IRMS), CHU of Caen, France.

Mauvieux B., LaRue J., Gouthière L., Sesboüe B. et Davenne D. (2004). (Influence of the level of physical training and sportive activity on the capacity to produce a focusing task for technicians in night-shift work). Influence du niveau d’entraînement physique et sportif sur la capacité à produire une tâche attentionnelle chez des techniciens en poste de nuit. Journées Nationales d’Etudes de la Société Française de Psychologie du Sport, UFR-APS de Grenoble, Grenoble, France, April 1-2 2004. (Abstract ), (Poster )

(1, 2, 5) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France (3) Laboratory of applied statistics and biomedical computing (Expert Soft Tech.), Esvres, France, (4) Regional Institute of Sport Medicine (IRMS), CHU of Caen, France.

Mauvieux B., Gouthière L., Sesboüe B. et Davenne D. (2005). (Physical training and sportive activities effects on the biological rhythms and on the sleep quality of the night-shift workers). Effets de l'entraînement physique et sportif sur les rythmes biologiques et sur la qualité du sommeil des travailleurs de nuit. XI. International ACAPS Conference (Association des Chercheurs en Activités Physiques et Sportives), October 26-28 2005, Paris, France. (Abstract ), (Poster )

(1, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (2) Laboratory of applied statistics (Expert Soft Tech.) Esvres, France, (3) Regional Institute of Sport Medicine (IRMS), CHU of Caen, France.

Gueugneau N., Mauvieux B. et Papaxanthis C. (2005). (The mental image of movement and circadian influence: Is isochrony persistent throughout the day). Image mentale du mouvement et influence circadienne : L’isochronie est-elle persistante tout au long de la journée. XI. International ACAPS Conference, October 26-28 2005, Paris, France. (Poster )

(1, 3) INSERM ERM 207 Motivity-Plasticity, UFR STAPS, University of Bourgogne, Dijon, France, (2) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France and Laboratory of applied statistics and biomedical computing (Expert Soft Tech.) Esvres, France.

Mauvieux B., Gouthière L., Waterhouse J. et Davenne D. (2006). (Modeling by the method of the sliding window for the study of the dynamic variations of the circadian rythmicity of the temperature when the external synchronizers of the intern clock are disturbed: jet lag and constant routine). Modélisation par la méthode des fenêtres glissantes des variations dynamiques de la rythmicité circadienne de la température lorsque les synchroniseurs externes de l'horloge interne sont perturbés : jet lag et constant routine.. XXXVIII. Congress of the French Society of Chronobiology, May 9-11 2006, Lyon, France. (Poster )

(1, 2, 4) Laboratory of the research center in physical and sport activities (CRAPS) UPRES EA 2131, University of Caen, France, (1, 2) Laboratory of applied statistics (Expert Soft Tech.) Esvres, France, (1, 3) Research institute for sport and exercise sciences, John Moores University, Liverpool, UK.

Benoit Mauvieux, Thesis viva, University of Caen Ph.D., December 3rd 2004, Title: (Effects of the regular physical and sporting training programme, chronic or temporary, on the biological rhythms in night-shift work). Effets d'un entrainement physique et sportif régulier, chronique ou temporaire, sur les rythmes biologiques du travailleur de nuit (Abstract )

Thesis Dir. : D. Davenne , Jury : D. Davenne (PU Caen Univ.), G. Falgairette (PU Toulon Univ.), J. Foret (CNRS Caen Dir.), A. Muzet (CNRS Strasbourg Dir.), A. Reinberg (CNRS Paris Dir.), L. Gouthière (Eng. Expert Soft Tech. Lab.)